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Background: CD47 is a novel therapeutic target in the treatment of solid-organ and hematologic malignancies. CD47 is also expressed on RBCs. Here, we report our experience of the RBC effects and the impact on blood bank testing and transfusion management in a Phase 1 trial of the humanized anti-CD47 monoclonal antibody Hu5F9-G4 in relapsed or primary refractory acute myeloid leukemia (AML
Publiceringsår: 2006. No ratings. Ämnesord: Specialtidningar. Finns som: Vald medietyp: Tidskrift (2006).
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CD47 is expressed on almost all normal human cells, as evaluated by mRNA expression and immunohistochemical staining, and occurs in four highly conserved isoforms that differ only in the length of their cytoplasmic domain, ranging from 3 to 36 amino acids (Reinhold et al., 1995). cd47 (iap, mer6, oa3) Tissue specificity i The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA , GTEX and FANTOM5 . 2020-07-16 2020-06-23 When a cell senses an infectious agent with molecules called pathogen recognition receptors, part of its response is to increase cell surface expression of a molecule called CD47, otherwise known as … CD47 on erythrocytes inhibits phagocytosis through interaction with the inhibitory immunoreceptor SIRPα expressed by macrophages. Thus, the CD47-SIRPα interaction constitutes a negative signal for erythrocyte phagocytosis. CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. CD47.
cd47抗体治疗后，cd47+红细胞枯竭，造成短暂性的贫血是其主要的不良反应。 虽然该不良反应在临床上比较好控制，但是CD47抗体治疗是否真的对正常组织没有伤害，是目前最为重要的一个问题[8]。
CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. CD47.
Proteinet CD47 kan binda till immunförsvarets fagocyter som kan Forskarna antog därför att mängden CD47 minskar på apoptotiska celler.
I policyn beskrivs vilka uppgifter vi samlar in, i vilket syfte och på vilket sätt du kan ha kontroll EPSON Panel Unit Cd47 Iei (1656227) EPSON Panel Unit Cd47 Iei. Inte på lager. Kontakta mig när varan finns i lager. 468:- 374,40 ex moms. Swedish University dissertations (essays) about CD47. Search and download thousands of Swedish university dissertations. Full text.
Åland, befolkade platser [sv].
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December 6, 2020 — TTI-622, an investigational CD47 inhibitor, showed preliminary signs of clinical activity with a manageable safety profile among patients with relapsed/refractory lymphoma. Although CD47-SIRPα interaction is well known for its ability to inhibit phagocytosis of CD47-expressing cells, 12,19 there have been several reports that provide evidence for a role for CD47 and SIRPα in promoting uptake of apoptotic cells.
CD47 is expressed on almost all normal human cells, as evaluated by mRNA expression and immunohistochemical staining, and occurs in four highly conserved isoforms that differ only in the length of their cytoplasmic domain, ranging from 3 to 36 amino acids (Reinhold et al., 1995). cd47 (iap, mer6, oa3) Tissue specificity i The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA , GTEX and FANTOM5 . 2020-07-16
2020-06-23
When a cell senses an infectious agent with molecules called pathogen recognition receptors, part of its response is to increase cell surface expression of a molecule called CD47, otherwise known as …
CD47 on erythrocytes inhibits phagocytosis through interaction with the inhibitory immunoreceptor SIRPα expressed by macrophages. Thus, the CD47-SIRPα interaction constitutes a negative signal for erythrocyte phagocytosis.
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CD47 is a glycosylated five transmembrane protein with a small alternatively spliced cytoplasmic domain. CD47 is involved in adhesion through interactions with
study demonstrates that antigen-presenting cells(CD47+) in coculture with human macrophages show a CD47 concentration-dependent inhibition of phagocytosis; CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. CD47. CD47 is a kind of protein that is found on the surface of many cells in the body. It tells circulating immune cells called macrophages not to eat these cells.
Swedish University dissertations (essays) about CD47. Search and download thousands of Swedish university dissertations. Full text. Free.
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ljusskillnaden kan färgen vara något annorlunda 2. Tillåt 1-5 mm skillnader på grund av manuell mätning. Artikel.nr.3a777e0d-cd47-472e-89bf-60f5583e44d0 och lätt ramverk.